Engineering the Active Site Pocket to Enhance the Catalytic Efficiency of a Novel Feruloyl Esterase Derived From Human Intestinal Bacteria Dorea formicigenerans

Engineering the Active Site Pocket to Enhance the Catalytic Efficiency of a Novel Feruloyl Esterase Derived From Human Intestinal Bacteria Dorea formicigenerans

The human gut microbiota play essential roles in metabolism and human health, especially by enzymatically utilizing dietary fiber that the host cannot directly digest and releasing functional components including short-chain fatty acids (SCFAs) and hydroxycinnamic acids (e.g., ferulic acid). In our...

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Bibliographic Details
Main Authors: Yang Shen, Yulu Wang, Xue Wei, Boting Wen, Shujun Liu, Huishuang Tan, Jingjian Zhang, Shuli Shao, Fengjiao Xin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
feruloyl esterase
gut microbiota
Dorea formicigenerans
AlphaFold2
rational design
substrate access tunnel
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.936914/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.936914/full

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