Identification of Novel Inhibitors of <i>Escherichia coli</i> DNA Ligase (LigA)

Identification of Novel Inhibitors of <i>Escherichia coli</i> DNA Ligase (LigA)

Present in all organisms, DNA ligases catalyse the formation of a phosphodiester bond between a 3′ hydroxyl and a 5′ phosphate, a reaction that is essential for maintaining genome integrity during replication and repair. Eubacterial DNA ligases use NAD<sup>+</sup> as a cofactor and posse...

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Bibliographic Details
Main Authors: Arqam Alomari, Robert Gowland, Callum Southwood, Jak Barrow, Zoe Bentley, Jashel Calvin-Nelson, Alice Kaminski, Matthew LeFevre, Anastasia J. Callaghan, Helen A. Vincent, Darren M. Gowers
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
antibacterial target
chemical inhibitors
DNA ligase
molecular docking
NAD<sup>+</sup>-dependent
Online Access:https://www.mdpi.com/1420-3049/26/9/2508

Internet

https://www.mdpi.com/1420-3049/26/9/2508

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