Hepatitis C virus induced endothelial inflammatory response depends on the functional expression of TNFα receptor subtype 2.

In hepatitis C virus (HCV) infection, morbidity and mortality often result from extrahepatic disease manifestations. We provide evidence for a role of receptors of the innate immune system in virally induced inflammation of the endothelium in vitro and in vivo. Corresponding to the in vitro finding...

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Main Authors: Joachim Pircher, Thomas Czermak, Monika Merkle, Hanna Mannell, Florian Krötz, Andrea Ribeiro, Volker Vielhauer, Jonathan Nadjiri, Erik Gaitzsch, Markus Niemeyer, Stefan Porubsky, Hermann-Josef Gröne, Markus Wörnle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113351&type=printable