3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations

3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations

Chromosome conformation capture techniques enable the study of genome organization in cancer cells. Here, the authors use Hi-C, WGS, and RNA-seq to study the 3D genome of multiple myeloma and find that genome disorganization is associated with copy number variations and changes in gene expression.

Bibliographic Details
Main Authors: Pengze Wu, Tingting Li, Ruifeng Li, Lumeng Jia, Ping Zhu, Yifang Liu, Qing Chen, Daiwei Tang, Yuezhou Yu, Cheng Li
Format: Article
Language:English
Published: Nature Portfolio 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01793-w

Internet

https://doi.org/10.1038/s41467-017-01793-w

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