Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection
Patient variables, such as comorbidities, partially explain which patients will progress to Klebsiella infection, with colonization of the gut acting as a reservoir. Little is known, however, regarding Klebsiella genes that may increase risk of disease in colonized individuals. Here, authors conduct...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31990-1 |
| _version_ | 1798037993437528064 |
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| author | Jay Vornhagen Emily K. Roberts Lavinia Unverdorben Sophia Mason Alieysa Patel Ryan Crawford Caitlyn L. Holmes Yuang Sun Alexandra Teodorescu Evan S. Snitkin Lili Zhao Patricia J. Simner Pranita D. Tamma Krishna Rao Keith S. Kaye Michael A. Bachman |
| author_facet | Jay Vornhagen Emily K. Roberts Lavinia Unverdorben Sophia Mason Alieysa Patel Ryan Crawford Caitlyn L. Holmes Yuang Sun Alexandra Teodorescu Evan S. Snitkin Lili Zhao Patricia J. Simner Pranita D. Tamma Krishna Rao Keith S. Kaye Michael A. Bachman |
| author_sort | Jay Vornhagen |
| collection | DOAJ |
| description | Patient variables, such as comorbidities, partially explain which patients will progress to Klebsiella infection, with colonization of the gut acting as a reservoir. Little is known, however, regarding Klebsiella genes that may increase risk of disease in colonized individuals. Here, authors conduct a comparative genomics study to identify genes associated with progression from colonisation to infection. |
| first_indexed | 2024-04-11T21:34:09Z |
| format | Article |
| id | doaj.art-9fca71bb880145e79855025ffb4001fa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T21:34:09Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9fca71bb880145e79855025ffb4001fa2022-12-22T04:01:48ZengNature PortfolioNature Communications2041-17232022-08-0113111510.1038/s41467-022-31990-1Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infectionJay Vornhagen0Emily K. Roberts1Lavinia Unverdorben2Sophia Mason3Alieysa Patel4Ryan Crawford5Caitlyn L. Holmes6Yuang Sun7Alexandra Teodorescu8Evan S. Snitkin9Lili Zhao10Patricia J. Simner11Pranita D. Tamma12Krishna Rao13Keith S. Kaye14Michael A. Bachman15Department of Pathology, Michigan Medicine, University of MichiganDepartment of Biostatistics, School of Public Health, University of MichiganDepartment of Microbiology & Immunology, Michigan Medicine, University of MichiganDepartment of Pathology, Michigan Medicine, University of MichiganDepartment of Pathology, Michigan Medicine, University of MichiganDepartment of Computational Medicine and Bioinformatics, Michigan Medicine, University of MichiganDepartment of Pathology, Michigan Medicine, University of MichiganDepartment of Pathology, Michigan Medicine, University of MichiganDepartment of Pathology, Michigan Medicine, University of MichiganDepartment of Microbiology & Immunology, Michigan Medicine, University of MichiganDepartment of Biostatistics, School of Public Health, University of MichiganDivision of Medical Microbiology, Department of Pathology, Johns Hopkins University School of MedicineDepartment of Pediatrics, Johns Hopkins University School of MedicineDepartment of Internal Medicine/Infectious Diseases Division, Michigan Medicine, University of MichiganDepartment of Internal Medicine/Infectious Diseases Division, Michigan Medicine, University of MichiganDepartment of Pathology, Michigan Medicine, University of MichiganPatient variables, such as comorbidities, partially explain which patients will progress to Klebsiella infection, with colonization of the gut acting as a reservoir. Little is known, however, regarding Klebsiella genes that may increase risk of disease in colonized individuals. Here, authors conduct a comparative genomics study to identify genes associated with progression from colonisation to infection.https://doi.org/10.1038/s41467-022-31990-1 |
| spellingShingle | Jay Vornhagen Emily K. Roberts Lavinia Unverdorben Sophia Mason Alieysa Patel Ryan Crawford Caitlyn L. Holmes Yuang Sun Alexandra Teodorescu Evan S. Snitkin Lili Zhao Patricia J. Simner Pranita D. Tamma Krishna Rao Keith S. Kaye Michael A. Bachman Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection Nature Communications |
| title | Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection |
| title_full | Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection |
| title_fullStr | Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection |
| title_full_unstemmed | Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection |
| title_short | Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection |
| title_sort | combined comparative genomics and clinical modeling reveals plasmid encoded genes are independently associated with klebsiella infection |
| url | https://doi.org/10.1038/s41467-022-31990-1 |
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