The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila

The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila

Abstract Background Ubiquitylation (ubi) of the intracellular domain of the Notch ligand Delta (Dl) by the E3 ligases Neuralized (Neur) and Mindbomb1 (Mib1) on lysines (Ks) is thought to be essential for the its signalling activity. Nevertheless, we have previously shown that DlK2R-HA, a Dl variant...

Full description

Bibliographic Details
Main Authors: Tobias Troost, Ekaterina Seib, Alina Airich, Nicole Vüllings, Aleksandar Necakov, Stefano De Renzis, Thomas Klein
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Biology
Subjects:
Cell communication
Notch
Delta
DSL-ligands
Ubiquitylation
E3-ligase
Online Access:https://doi.org/10.1186/s12915-023-01759-z

Internet

https://doi.org/10.1186/s12915-023-01759-z

Similar Items