Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
स्वरूप: लेख
भाषा:English
प्रकाशित: Elsevier 2013-06-01
श्रृंखला:Neurobiology of Disease
विषय:
Oxidative stress
Redox
TPI deficiency
Triose phosphate isomerase
Glycolytic enzymopathy
Drosophila
ऑनलाइन पहुंच:http://www.sciencedirect.com/science/article/pii/S0969996113000119

इंटरनेट

http://www.sciencedirect.com/science/article/pii/S0969996113000119

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