Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier 2013-06-01
Schriftenreihe:Neurobiology of Disease
Schlagworte:
Oxidative stress
Redox
TPI deficiency
Triose phosphate isomerase
Glycolytic enzymopathy
Drosophila
Online Zugang:http://www.sciencedirect.com/science/article/pii/S0969996113000119

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