Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

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Detalles Bibliográficos
Autores principales: Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
Formato: Artículo
Lenguaje:English
Publicado: Elsevier 2013-06-01
Colección:Neurobiology of Disease
Materias:
Oxidative stress
Redox
TPI deficiency
Triose phosphate isomerase
Glycolytic enzymopathy
Drosophila
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S0969996113000119

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