Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

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Dettagli Bibliografici
Autori principali:	Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
Natura:	Articolo
Lingua:	English
Pubblicazione:	Elsevier 2013-06-01
Serie:	Neurobiology of Disease
Soggetti:	Oxidative stress Redox TPI deficiency Triose phosphate isomerase Glycolytic enzymopathy Drosophila
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0969996113000119

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