Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
Format:	Artykuł
Język:	English
Wydane:	Elsevier 2013-06-01
Seria:	Neurobiology of Disease
Hasła przedmiotowe:	Oxidative stress Redox TPI deficiency Triose phosphate isomerase Glycolytic enzymopathy Drosophila
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S0969996113000119

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