LPAR1 regulates the development of intratumoral heterogeneity in ovarian serous cystadenocarcinoma by activating the PI3K/AKT signaling pathway

LPAR1 regulates the development of intratumoral heterogeneity in ovarian serous cystadenocarcinoma by activating the PI3K/AKT signaling pathway

Abstract Background To explore the role of lysophosphatidic acid receptor 1 (LPAR1) and its correlation with the PI3K/AKT pathway in the development of intratumoral heterogeneity (ITH) in human ovarian serous cystadenocarcinoma (OSC). Methods Immunohistochemical staining was performed to detect LPAR...

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Bibliographic Details
Main Authors: Ran Cui, Guangming Cao, Huimin Bai, Zhenyu Zhang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cancer Cell International
Subjects:
Ovarian serous cystadenocarcinoma
Intratumoral heterogeneity
LPAR1
PI3K/AKT pathway
Single-cell subclones
Online Access:http://link.springer.com/article/10.1186/s12935-019-0920-0

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http://link.springer.com/article/10.1186/s12935-019-0920-0

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