Emergence of KPC-113 and KPC-114 variants in ceftazidime-avibactam-resistant Klebsiella pneumoniae belonging to high-risk clones ST11 and ST16 in South America

Emergence of KPC-113 and KPC-114 variants in ceftazidime-avibactam-resistant Klebsiella pneumoniae belonging to high-risk clones ST11 and ST16 in South America

ABSTRACT Two novel variants of Klebsiella pneumoniae carbapenemase (KPC) associated with resistance to ceftazidime-avibactam (CZA) and designated as KPC-113 and KPC-114 by NCBI were identified in 2020, in clinical isolates of Klebsiella pneumoniae in Brazil. While K. pneumoniae of ST16 harbored the...

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Bibliographic Details
Main Authors: Felipe Vásquez-Ponce, Jessica Bispo, Johana Becerra, Herrison Fontana, Jesus G. M. Pariona, Fernanda Esposito, Bruna Fuga, Flavio A. Oliveira, Florencia Brunetti, Pablo Power, Gabriel Gutkind, Angelica Zaninelli Schreiber, Nilton Lincopan
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
antimicrobial resistance
KPC variants
ceftazidime-avibactam
Enterobacterales
international clones
genomic surveillance
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00374-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00374-23

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