Theory for the optimal detection of time-varying signals in cellular sensing systems

Living cells often need to measure chemical concentrations that vary in time, yet how accurately they can do so is poorly understood. Here, we present a theory that fully specifies, without any adjustable parameters, the optimal design of a canonical sensing system in terms of two elementary design...

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Bibliographic Details
Main Authors: Giulia Malaguti, Pieter Rein ten Wolde
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/62574