A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes

A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes

Abstract Global eradication of poliovirus remains elusive, and it is critical to develop next generation vaccines and antivirals. In support of this goal, we map the epitope of human monoclonal antibody 9H2 which is able to neutralize the three serotypes of poliovirus. Using cryo-EM we solve the nea...

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Bibliographic Details
Main Authors: Andrew J. Charnesky, Julia E. Faust, Hyunwook Lee, Rama Devudu Puligedda, Daniel J. Goetschius, Nadia M. DiNunno, Vaskar Thapa, Carol M. Bator, Sung Hyun (Joseph) Cho, Rahnuma Wahid, Kutub Mahmood, Scott Dessain, Konstantin M. Chumakov, Amy Rosenfeld, Susan L. Hafenstein
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41052-9

Internet

https://doi.org/10.1038/s41467-023-41052-9

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