Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome

Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome

Bile acids (BA) are amphiphilic molecules synthesized in the liver from cholesterol. BA undergo continuous enterohepatic recycling through intestinal biotransformation by gut microbiome and reabsorption into the portal tract for uptake by hepatocytes. BA are detergent molecules aiding the digestion...

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Bibliographic Details
Main Authors: Piero Portincasa, Agostino Di Ciaula, Gabriella Garruti, Mirco Vacca, Maria De Angelis, David Q.-H. Wang
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Nutrients
Subjects:
bile
cholestasis
FXR
metabolic syndrome
nuclear receptors
TGR5
Online Access:https://www.mdpi.com/2072-6643/12/12/3709

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https://www.mdpi.com/2072-6643/12/12/3709

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