Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults

Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults

Introduction:Centella asiatica is an herbaceous plant reputed in Eastern medicine to improve memory. Preclinical studies have shown that C. asiatica aqueous extract (CAW) improves neuronal health, reduces oxidative stress, and positively impacts learning and cognition. This study aimed to develop an...

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Bibliographic Details
Main Authors: Kirsten M. Wright, Melissa Bollen, Jason David, Bridgette Mepham, Armando Alcázar Magaña, Christine McClure, Claudia S. Maier, Joseph F. Quinn, Amala Soumyanath
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
Centella asiatica
pharmacokinetics
validation
pharmacodynamics
Alzheimer’s disease
caffeoylquinic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1228030/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1228030/full

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