Binding modes of potential anti-prion phytochemicals to PrPC structures in silico

Binding modes of potential anti-prion phytochemicals to PrPC structures in silico

Background: Prion diseases involve the conversion of a normal, cell-surface glycoprotein (PrPC) into a misfolded pathogenic form (PrPSc). One possible strategy to inhibit PrPSc formation is to stabilize the native conformation of PrPC and interfere with the conversion of PrPC to PrPSc. Many compound...

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Bibliographic Details
Main Authors: Sandesh Neupane, Jenisha Khadka, Sandesh Rayamajhi, Arti S. Pandey
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Journal of Ayurveda and Integrative Medicine
Subjects:
anti-Prion
Phytochemicals
Terpenes
Quinones
Sterols
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0975947623000669

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http://www.sciencedirect.com/science/article/pii/S0975947623000669

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