FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery

FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery

The pivotal role of myofibroblast contractility in the pathophysiology of fibrosis is widely recognized, yet HTS approaches are not available to quantify this critically important function in drug discovery. We developed, validated, and scaled-up a HTS platform that quantifies contractile function o...

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Bibliographic Details
Main Authors: Yao Wang, Enrico Cortes, Ricky Huang, Jeremy Wan, Junyi Zhao, Boris Hinz, Robert Damoiseaux, Ivan Pushkarsky
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:SLAS Discovery
Subjects:
Fibrosis
Myofibroblast
TGFB
Contractility
Scarring
Activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555223001090

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http://www.sciencedirect.com/science/article/pii/S2472555223001090

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