Pharmacokinetic and Pharmacogenetic Factors Contributing to Platelet Function Recovery After Single Dose of Ticagrelor in Healthy Subjects

Pharmacokinetic and Pharmacogenetic Factors Contributing to Platelet Function Recovery After Single Dose of Ticagrelor in Healthy Subjects

Objectives: This study aimed to elucidate the contribution of candidate single nucleotide polymorphisms (SNPs) related to pharmacokinetics on the recovery of platelet function after single dose of ticagrelor was orally administered to healthy Chinese subjects.Methods: The pharmacokinetic profiles of...

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Bibliographic Details
Main Authors: Qian Zhu, Wanping Zhong, Xipei Wang, Liping Mai, Guodong He, Jiyan Chen, Lan Tang, Shuwen Liu, Weihua Lai, Shilong Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
genetic variants
healthy subjects
pharmacokinetics
recovery of platelet function
ticagrelor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00209/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00209/full

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