An Integrative Transcriptome-Wide Analysis of Amyotrophic Lateral Sclerosis for the Identification of Potential Genetic Markers and Drug Candidates

An Integrative Transcriptome-Wide Analysis of Amyotrophic Lateral Sclerosis for the Identification of Potential Genetic Markers and Drug Candidates

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative neuromuscular disease. Although genome-wide association studies (GWAS) have successfully identified many variants significantly associated with ALS, it is still difficult to characterize the underlying biological mechanisms inducing ALS. In...

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Bibliographic Details
Main Authors: Sungmin Park, Daeun Kim, Jaeseung Song, Jong Wha J. Joo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
transcriptome-wide association study
drug repositioning
enrichment analysis
causal gene
Online Access:https://www.mdpi.com/1422-0067/22/6/3216

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