Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

Abstract Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CNS repair, in particular remyelination. Microglia play a pivotal role in regulating...

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Bibliographic Details
Main Authors: Nicolau Beckmann, Elisa Giorgetti, Anna Neuhaus, Stefan Zurbruegg, Nathalie Accart, Paul Smith, Julien Perdoux, Ludovic Perrot, Mark Nash, Sandrine Desrayaud, Peter Wipfli, Wilfried Frieauff, Derya R. Shimshek
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Acta Neuropathologica Communications
Subjects:
Neuroinflammation
Microglia
Astrocyte
Cuprizone
Myelination
Multiple sclerosis
Online Access:http://link.springer.com/article/10.1186/s40478-018-0510-8

Internet

http://link.springer.com/article/10.1186/s40478-018-0510-8

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