HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice

HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice

Regulatory T (Treg) cells are essential to maintain immune homeostasis in the intestine and Treg cell dysfunction is associated with several inflammatory and autoimmune disorders including inflammatory bowel disease (IBD). Efforts using low-dose (LD) interleukin-2 (IL-2) to expand autologous Treg ce...

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Bibliographic Details
Main Authors: Rajeev K. Tyagi, Justin Jacobse, Jing Li, Margret M. Allaman, Kevin L. Otipoby, Erik R. Sampson, Keith T. Wilson, Jeremy A. Goettel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
IBD
IL-2
humanized
colitis
Tregs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.630204/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.630204/full

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