Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV

Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV

Tuberculosis owes its resurgence as a major global health threat mostly to the emergence of drug resistance and coinfection with HIV. The synergy between HIV and Mycobacterium tuberculosis (Mtb) modifies the host immune environment to enhance both viral and bacterial replication and spread. In the l...

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Bibliographic Details
Main Authors: David Pires, Marta Calado, Tomás Velez, Manoj Mandal, Maria João Catalão, Olivier Neyrolles, Geanncarlo Lugo-Villarino, Christel Vérollet, José Miguel Azevedo-Pereira, Elsa Anes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
cystatins
cathepsins
tuberculosis
HIV/Mtb coinfection
host-directed therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.742822/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.742822/full

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