An Early Myelosuppression in the Acute Mouse Sepsis Is Partly Outcome-Dependent

An Early Myelosuppression in the Acute Mouse Sepsis Is Partly Outcome-Dependent

Adult hematopoietic stem and progenitor cells (HSPCs) respond to bacterial infections by expansion to myeloid cells. Sepsis impairs this process by suppressing differentiation of stem cells subsequently contributing to an ineffective immune response. Whether the magnitude of HSPCs impairment in seps...

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Bibliographic Details
Main Authors: Tomasz Skirecki, Susanne Drechsler, Aldona Jeznach, Grażyna Hoser, Mohammad Jafarmadar, Jerzy Kawiak, Marcin F. Osuchowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
infection
cecal ligation and puncture
hematopoietic stem and progenitor cells
outcome prediction
immunity
caspases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.708670/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.708670/full

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