The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signalling

The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signalling

Abstract Colorectal cancer (CRC) is the second leading cause of cancer deaths. Though chemotherapy is the main treatment option for advanced CRC, patients invariably acquire resistance to chemotherapeutic drugs and fail to respond to the therapy. Although understanding the mechanisms regulating chem...

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Bibliographic Details
Main Authors: Sushma Anand, Christina Nedeva, Sai V. Chitti, Pamali Fonseka, Taeyoung Kang, Lahiru Gangoda, Nishat I. Tabassum, Suad Abdirahman, Thiruma V. Arumugam, Tracy L. Putoczki, Sharad Kumar, Suresh Mathivanan
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06349-z

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https://doi.org/10.1038/s41419-023-06349-z

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