Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis

Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis

Abstract Some individuals develop prediabetes and/or diabetes following acute pancreatitis (AP). AP-induced beta-cell injury and the limited regenerative capacity of beta cells might account for pancreatic endocrine insufficiency. Previously, we found that only a few pancreatic cytokeratin 5 positiv...

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Bibliographic Details
Main Authors: Xiaoyi Zhang, Jing Tao, Jia Yu, Ning Hu, Xuanzhe Zhang, Guirong Wang, Jiarui Feng, Xingcheng Xiong, Man Li, Dongqi Chai, Hanjun Li, Yuping Rong, Zhigang Tang, Weixing Wang, Zhiyong Peng, Qiao Shi
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04160-2

Internet

https://doi.org/10.1038/s41419-021-04160-2

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