Fn14-targeted BiTE and CAR-T cells demonstrate potent preclinical activity against glioblastoma

Fn14-targeted BiTE and CAR-T cells demonstrate potent preclinical activity against glioblastoma

T cell-engaging therapies involving bispecific T cell engager (BiTE) and chimeric antigen receptor T (CAR-T) cells have achieved great success in the treatment of hematological tumors. However, the paucity of ideal cell surface molecules that can be targeted on glioblastoma (GBM) partially reduces t...

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Bibliographic Details
Main Authors: Gaowei Li, Zongliang Zhang, Linjun Cai, Xin Tang, Jianhan Huang, Lingyu Yu, Guoqing Wang, Kunhong Zhong, Yi Cao, Chang Liu, Yuelong Wang, Aiping Tong, Liangxue Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
gbm
fn14
bite
car-t
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1983306

Internet

http://dx.doi.org/10.1080/2162402X.2021.1983306

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