Nitroglycerin and Iloprost Improve Mitochondrial Function in Colon Homogenate Without Altering the Barrier Integrity of Caco-2 Monolayers

Nitroglycerin and Iloprost Improve Mitochondrial Function in Colon Homogenate Without Altering the Barrier Integrity of Caco-2 Monolayers

Locally applied nitroglycerin [nitric oxide (NO) donor] and iloprost (analog of prostacyclin PGI2) improve regional gastric oxygenation and nitroglycerin preserves gastric mucosal barrier integrity. This suggests direct effects of these substances on oxygenation and barrier function. The aim of this...

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Bibliographic Details
Main Authors: Anna Herminghaus, Rebecca Eberhardt, Richard Truse, Jan Schulz, Inge Bauer, Olaf Picker, Christian Vollmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Medicine
Subjects:
nitroglycerin
iloprost
mitochondrial respiration
barrier function
Caco-2 cells
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2018.00291/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2018.00291/full

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