FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common cause of inherited intellectual disability, yet it is unknown how FMRP function varies across brain regions and cell types and how this contributes to disease pathophysiology. Here we use conditional tagging of FMR...

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Bibliographic Details
Main Authors: Kirsty Sawicka, Caryn R Hale, Christopher Y Park, John J Fak, Jodi E Gresack, Sarah J Van Driesche, Jin Joo Kang, Jennifer C Darnell, Robert B Darnell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
fragile X syndrome
FMRP
autism
circadian rhythm
CA1 pyramidal neurons
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Online Access:https://elifesciences.org/articles/46919

Internet

https://elifesciences.org/articles/46919

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