STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome

STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome

The activation of stimulator of interferon genes (STING) and NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis signaling pathways represent two distinct central mechanisms in liver disease. However, the interconnections between these two pathways and the epigenetic regulation of t...

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Bibliographic Details
Main Authors: Yang Xiao, Chong Zhao, Yang Tai, Bei Li, Tian Lan, Enjiang Lai, Wenting Dai, Yangkun Guo, Can Gan, Enis Kostallari, Chengwei Tang, Jinhang Gao
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
Liver cirrhosis
GSDMD
IRF3
Histone methylation
Oxidative stress
Metabolic reprogramming
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000927

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http://www.sciencedirect.com/science/article/pii/S2213231723000927

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