Translocating proteins compartment-specifically alter the fate of epithelial-mesenchymal transition in a compartmentalized Boolean network model

Abstract Regulation of translocating proteins is crucial in defining cellular behaviour. Epithelial-mesenchymal transition (EMT) is important in cellular processes, such as cancer progression. Several orchestrators of EMT, such as key transcription factors, are known to translocate. We show that tra...

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Bibliographic Details
Main Authors: Péter Mendik, Márk Kerestély, Sebestyén Kamp, Dávid Deritei, Nina Kunšič, Zsolt Vassy, Péter Csermely, Daniel V. Veres
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-022-00228-7