Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice

Rationale: Liver cirrhosis is known to affect drug pharmacokinetics, but the functional assessment of the underlying pathophysiological alterations in drug metabolism is difficult.Methods: Cirrhosis in mice was induced by repeated treatment with carbon tetrachloride for 12 months. A cocktail of six...

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Main Authors: Rebekka Fendt, Ahmed Ghallab, Maiju Myllys, Ute Hofmann, Reham Hassan, Zaynab Hobloss, Daniela González, Lisa Brackhagen, Rosemarie Marchan, Karolina Edlund, Abdel-Latif Seddek, Noha Abdelmageed, Lars M. Blank, Jan-Frederik Schlender, Christian H. Holland, Jan G. Hengstler, Lars Kuepfer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
drug metabolism
liver cirrhosis
sinusoidal transport
glucuronides
drug cocktail
PBPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1279357/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1279357/full

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