Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (mHtt) protein. Here the authors suggest that mHtt promotes ribosome stalling and inhibits protein synthesis.

Bibliographic Details
Main Authors: Mehdi Eshraghi, Pabalu P. Karunadharma, Juliana Blin, Neelam Shahani, Emiliano P. Ricci, Audrey Michel, Nicolai T. Urban, Nicole Galli, Manish Sharma, Uri Nimrod Ramírez-Jarquín, Katie Florescu, Jennifer Hernandez, Srinivasa Subramaniam
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21637-y

Internet

https://doi.org/10.1038/s41467-021-21637-y

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