Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation

Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation

Abstract Background Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorably promote tumor progression through paracrine secretion of the senescence-associated secretory phenotype (SASP). Extracellular vesicles (EVs) have recently em...

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Bibliographic Details
Main Authors: Dan Zhang, Jian-Wei Zhang, Hui Xu, Xin Chen, Yu Gao, Huan-Gang Jiang, You Wang, Han Wu, Lei Yang, Wen-Bo Wang, Jing Dai, Ling Xia, Jin Peng, Fu-Xiang Zhou
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Molecular Cancer
Subjects:
Cellular senescence
Extracellular vesicles
Colorectal cancer
SERPINE1
p65
Online Access:https://doi.org/10.1186/s12943-024-01985-1

Internet

https://doi.org/10.1186/s12943-024-01985-1

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