LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β<sub>1-42</sub> Fibrils

LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β<sub>1-42</sub> Fibrils

Intracerebral accumulation of amyloid-β in the extracellular plaques of Alzheimer’s disease (AD) brains represents the main cause of reactive astrogliosis and neuroinflammatory response. Of relevance, leucine-rich repeat kinase 2 (LRRK2), a kinase linked to genetic and sporadic Parkinson’s disease (...

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Bibliographic Details
Main Authors: Alice Filippini, Valentina Salvi, Vincenzo Dattilo, Chiara Magri, Stefania Castrezzati, Robert Veerhuis, Daniela Bosisio, Massimo Gennarelli, Isabella Russo
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
LRRK2
Alzheimer’s disease
astrocytes
amyloid-β
neuroinflammation
Online Access:https://www.mdpi.com/2218-273X/13/2/307

Internet

https://www.mdpi.com/2218-273X/13/2/307

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