Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia

Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia

Abstract Motivational deficits play a central role in disability due to negative symptoms of schizophrenia (SZ), but limited pathophysiological understanding impedes critically needed therapeutic development. We applied an fMRI Effort Discounting Task (EDT) that quantifies motivation using a neuroec...

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Bibliographic Details
Main Authors: Greer E. Prettyman, Joseph W. Kable, Paige Didier, Sheila Shankar, Theodore D. Satterthwaite, Christos Davatzikos, Warren B. Bilker, Mark A. Elliott, Kosha Ruparel, Daniel H. Wolf
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:npj Schizophrenia
Online Access:https://doi.org/10.1038/s41537-021-00178-9

Internet

https://doi.org/10.1038/s41537-021-00178-9

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