Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire

Abstract Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated. Countering models that presume antibodies are generated largely by stochastic processes, w...

Full description

Bibliographic Details
Main Authors: Oscar L. Rodriguez, Yana Safonova, Catherine A. Silver, Kaitlyn Shields, William S. Gibson, Justin T. Kos, David Tieri, Hanzhong Ke, Katherine J. L. Jackson, Scott D. Boyd, Melissa L. Smith, Wayne A. Marasco, Corey T. Watson
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40070-x

Internet

https://doi.org/10.1038/s41467-023-40070-x

Similar Items