High-level nitrofurantoin resistance in a clinical isolate of Klebsiella pneumoniae: a comparative genomics and metabolomics analysis

High-level nitrofurantoin resistance in a clinical isolate of Klebsiella pneumoniae: a comparative genomics and metabolomics analysis

ABSTRACTNitrofurantoin is a commonly used chemotherapeutic agent in the treatment of uncomplicated urinary tract infections caused by the problematic multidrug resistant Gram-negative pathogen Klebsiella pneumoniae. The present study aims to elucidate the mechanism of nitrofurantoin action and high-...

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Bibliographic Details
Main Authors: Maytham Hussein, Zetao Sun, Jane Hawkey, Rafah Allobawi, Louise M. Judd, Vincenzo Carbone, Rajnikant Sharma, Varsha Thombare, Mark Baker, Gauri G. Rao, Jian Li, Kathryn E. Holt, Tony Velkov
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mSystems
Subjects:
nitrofurantoin
Klebsiella pneumoniae
antimicrobial resistance
genomics
metabolomics
Online Access:https://journals.asm.org/doi/10.1128/msystems.00972-23

Internet

https://journals.asm.org/doi/10.1128/msystems.00972-23

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