Risperidone accelerates bone loss in mice models of schizophrenia by inhibiting osteoblast autophagy

Risperidone accelerates bone loss in mice models of schizophrenia by inhibiting osteoblast autophagy

Background: Risperidone (RIS) is the first-line drug in the clinical treatment of schizophrenia, and long-term use may lead to bone loss and even osteoporosis. This study investigated whether the mechanism of RIS-induced bone loss is related to autophagy. Methods: The schizophrenia mice were establi...

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Bibliographic Details
Main Authors: Zaihong Yang, Peifan Li, Hongyan Fan, Lan Pang, Guangyuan Xia, Changrong Duan, Lei Zheng
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
Risperidone
Bone loss
Schizophrenia
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024145902

Internet

http://www.sciencedirect.com/science/article/pii/S2405844024145902

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