Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy

Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy

Abstract Background Cancer stem cells (CSCs) are crucial for the growth, metastasis, drug resistance, recurrence, and spread of tumors. Napabucasin (NAP) could effectively inhibit CSC, but its mechanism has not been fully explained. Additionally, NAP also has the drawbacks of poor water solubility a...

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Bibliographic Details
Main Authors: Boping Jing, Feng Guo, Rui An, Yu Gao, Yuman Li, Yuji Xie, Jing Wang, Yihan Chen, He Li, Tang Gao, Qiaofeng Jin, Li Zhang, Mingxing Xie
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Nanobiotechnology
Subjects:
Cancer stem cells
Napabucasin
Tumor-derived microparticles
PET/CT imaging
JAK-STAT pathway
Online Access:https://doi.org/10.1186/s12951-023-01792-8

Internet

https://doi.org/10.1186/s12951-023-01792-8

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