Identification of BRCA1/2 mutation female carriers using circulating microRNA profiles

Identification of BRCA1/2 mutation female carriers using circulating microRNA profiles

Abstract Identifying germline BRCA1/2 mutation carriers is vital for reducing their risk of breast and ovarian cancer. To derive a serum miRNA-based diagnostic test we used samples from 653 healthy women from six international cohorts, including 350 (53.6%) with BRCA1/2 mutations and 303 (46.4%) BRC...

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Bibliographic Details
Main Authors: Kevin Elias, Urszula Smyczynska, Konrad Stawiski, Zuzanna Nowicka, James Webber, Jakub Kaplan, Charles Landen, Jan Lubinski, Asima Mukhopadhyay, Dona Chakraborty, Denise C. Connolly, Heather Symecko, Susan M. Domchek, Judy E. Garber, Panagiotis Konstantinopoulos, Wojciech Fendler, Dipanjan Chowdhury
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38925-4

Internet

https://doi.org/10.1038/s41467-023-38925-4

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