Synthesis and Cytotoxic Activity of the Derivatives of <i>N</i>-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Synthesis and Cytotoxic Activity of the Derivatives of <i>N</i>-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Testing a number of <i>N</i>-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 murine m...

Full description

Bibliographic Details
Main Authors: Victor P. Krasnov, Olga A. Vozdvizhenskaya, Maria A. Baryshnikova, Alexandra G. Pershina, Vera V. Musiyak, Tatyana V. Matveeva, Kseniya V. Nevskaya, Olga Y. Brikunova, Dmitry A. Gruzdev, Galina L. Levit
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
purine
omega-amino acids
7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine
cytotoxicity
tumor cells
Online Access:https://www.mdpi.com/1420-3049/28/4/1853

Internet

https://www.mdpi.com/1420-3049/28/4/1853

Similar Items