Synthesis and Cytotoxic Activity of the Derivatives of <i>N</i>-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Synthesis and Cytotoxic Activity of the Derivatives of <i>N</i>-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Testing a number of <i>N</i>-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 murine m...

Full description

Bibliographic Details
Main Authors:	Victor P. Krasnov, Olga A. Vozdvizhenskaya, Maria A. Baryshnikova, Alexandra G. Pershina, Vera V. Musiyak, Tatyana V. Matveeva, Kseniya V. Nevskaya, Olga Y. Brikunova, Dmitry A. Gruzdev, Galina L. Levit
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Molecules
Subjects:	purine omega-amino acids 7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine cytotoxicity tumor cells
Online Access:	https://www.mdpi.com/1420-3049/28/4/1853

Similar Items

Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine and Evaluation of Their Antiviral Activity
by: Victor P. Krasnov, et al.
Published: (2022-06-01)

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach
by: Polya G. Roydeva, et al.
Published: (2016-01-01)

4-Benzoyl-2-(4-bromophenyl)-1-(4-methoxyphenyl)-1,2-dihydropyrimidino[4,3-<i>c</i>][1,4]benzoxazine-3,5-dione
by: Ekaterina E. Khramtsova, et al.
Published: (2023-02-01)

<i>N′</i>-Acetyl-3-methyl-1,6-diphenyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridine-4-carbohydrazide
by: Júlio C. A. V. Soares, et al.
Published: (2020-01-01)

Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region
by: Jacek Wierzchowski, et al.
Published: (2005-10-01)

Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides
by: Hang Ren, et al.
Published: (2015-12-01)

Microwave Assisted Synthesis of 2,2'-Arylene-substituted Bis(4H-3,1-Benzoxazin-4-one) Derivatives Using the Complex Cyanuric Chloride/N,N-Dimethylformamide
by: Mehdi Shariat, et al.
Published: (2012-09-01)

Synthesis of some Heterocyclic Compounds from 1,4-Benzoxazine-3-one
by: Omar A. Salih
Published: (2013-03-01)

2,6-Bis[4-(4-butylphenyl)-1<i>H</i>-1,2,3-triazol-1-yl]-9-dodecyl-9<i>H</i>-purine
by: Andrejs Šišuļins, et al.
Published: (2019-07-01)

Ethyl 4,4''-Difluoro-5'-hydroxy-1,1':3',1''-terphenyl-4'-carboxylate
by: Badiadka Narayana, et al.
Published: (2011-11-01)

Methyl 6,7-Difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate
by: Vladimir A. Potapov, et al.
Published: (2024-09-01)

Pharmacological and Chemical Potential of <i>Spiranthes sinensis</i> (Orchidaceae): A Narrative Review
by: Yu-Jen Kuo, et al.
Published: (2022-06-01)

Synthesis of purines and adenines containing the hexafluoroisopropyl group
by: Viacheslav Petrov, et al.
Published: (2020-11-01)

<i>Acanthus mollis</i> Formulations for Transdermal Delivery: From Hydrogels to Emulsions
by: Patrícia Matos, et al.
Published: (2023-12-01)

Synthesis of Polyfluorinated Thia- and Oxathiacalixarenes Based on Perfluoro-<i>m</i>-xylene
by: Vladimir N. Kovtonyuk, et al.
Published: (2021-01-01)

Behaviour of some newly synthesized substituted 1,2,4-triazoline-3-thiones in sulfuric acid media
by: Mirjana Jankulovska, et al.
Published: (2006-06-01)

Efficient Synthesis of Novel Triazolo[5,1-<i>b</i>]purines by Diacetoxyiodobenzene-Mediated Oxidative Cyclization of Schiff Bases
by: Artyom O. Neymash, et al.
Published: (2024-12-01)

Novel Purine Chemotypes with Activity against <i>Plasmodium falciparum</i> and <i>Trypanosoma cruzi</i>
by: Nieves Martinez-Peinado, et al.
Published: (2021-07-01)

Synthesis of Pyridinium Moiety Containing Triazolyl Purines
by: Aleksejs Burcevs, et al.
Published: (2024-07-01)

Synthesis of 3-{4-[4-(Benzylideneamino)benzenesulfonyl]- phenyl}-2-phenylquinazolin-4(3H)-one
by: Sunil Manohar Babu, et al.
Published: (2009-01-01)

Microwave Irradiation Promoted Reactions of Benzoxazin-4-Ones with Primary Amines. Preparation of 4(2=3H)-Quinazolinones
by: Mohammad Sadegh Khajavi, et al.
Published: (1999-06-01)

Purine metabolism in plant pathogenic fungi
by: Manli Sun, et al.
Published: (2024-02-01)

A microwave-catalyzed rapid, efficient and ecofriendly synthesis of substituted pyrazol-5-ones
by: RAHUL P. GAVANDE, et al.
Published: (2003-10-01)

A microwave-catalyzed rapid, efficient and ecofriendly synthesis of substituted pyrazol-5-ones (Short communication)
by: Dabholkar Vijay V., et al.
Published: (2003-01-01)

Recent Progress in the Synthesis of Benzoxazin-4-Ones, Applications in N-Directed Ortho-Functionalizations, and Biological Significance
by: Ziad Moussa, et al.
Published: (2024-12-01)

High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias
by: Hong Li, et al.
Published: (2008-01-01)

Purine Auxotrophic Starvation Evokes Phenotype Similar to Stationary Phase Cells in Budding Yeast
by: Agnese Kokina, et al.
Published: (2021-12-01)

A Convenient Method to Prepare Labile FMN Derivatives
by: John Lee, et al.
Published: (2001-10-01)

4<i>H</i>-Benzo[<i>d</i>][1,3]oxazin-4-ones and Dihydro Analogs from Substituted Anthranilic Acids and Orthoesters
by: Joel K. Annor-Gyamfi, et al.
Published: (2019-10-01)

Synthesis and Evaluation of Self-Assembling Properties of 3-(3,5-Difluoro-3,5-bis((alkoxy)carbonyl)-2,6-dioxoheptan-4-yl)-1-methylpyridin-1-ium Iodides
by: Nadiia Pikun, et al.
Published: (2022-07-01)

Synthesis of Chiral 1,4,2-Oxazaphosphepines
by: Oscar Salgado-Escobar, et al.
Published: (2015-07-01)

Diastereoselective synthesis of 3,4-dihydro-2H-pyran-4-carboxamides through an unusual regiospecific quasi-hydrolysis of a cyano group
by: Mikhail Yu. Ievlev, et al.
Published: (2016-09-01)

Silica-bound benzoyl chloride mediated the solid-phase synthesis of 4H-3,1-benzoxazin-4-ones
by: Kurosh Rad-Moghadam, et al.
Published: (2009-04-01)

Terpenyl-Purines from the Sea
by: Marina Gordaliza
Published: (2009-12-01)

Diagnostic value of determining the level of purine metabolism intermediates in pregnant women with chronic hypertension and superimposed preeclampsia
by: Dinara Omertayeva, et al.
Published: (2021-07-01)

Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues
by: Reda M. Abdel-Rahman, et al.
Published: (2017-05-01)

6-Phenyl-2-(4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one
by: Mohammad Shaharyar, et al.
Published: (2010-10-01)

6′-Amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1′<i>H</i>-spiro[indoline-3,4′-pyrano[2,3-<i>c</i>]pyrazole]-5′-carbonitrile
by: Yuliya E. Ryzhkova, et al.
Published: (2021-12-01)

Synthesis, Spectroscopic Studies and Keto-Enol Tautomerism of Novel 1,3,4-Thiadiazole Derivative Containing 3-Mercaptobutan-2-one and Quinazolin-4-one Moieties
by: Sewara J. Mohammed, et al.
Published: (2020-11-01)

The Key Role of Purine Metabolism in the Folate-Dependent Phenotype of Autism Spectrum Disorders: An In Silico Analysis
by: Jan Geryk, et al.
Published: (2020-05-01)