Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying

Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying

Co-suspension drug-loading technology, namely Aerosphere™, can improve fine particle fraction (FPF) and delivered dose content uniformity (DDCU). However, because of its poor drug-loading efficacy, the phospholipid carrier dosage in Aerosphere™ is usually dozens of times greater than that of the dru...

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Bibliographic Details
Main Authors: Quan Xi, Jiaying Miao, Zhen Cao, Hao Wang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Inhalable microparticles
Pressurized metered dose inhaler
Aerodynamic performance
Delivered dose content uniformity
Spray-freeze-drying
Drug-loading method
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156723000026

Internet

http://www.sciencedirect.com/science/article/pii/S2590156723000026

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