Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction

BackgroundDiabetes mellitus (DM) is associated with mitochondrial oxidative stress. We have shown that myocardial oxidative stress leads to diastolic dysfunction in a hypertensive mouse model. Therefore, we hypothesized that diabetes mellitus could cause diastolic dysfunction through mitochondrial o...

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Bibliographic Details
Main Authors: Euy‐Myoung Jeong, Jaehoon Chung, Hong Liu, Yeongju Go, Scott Gladstein, Afshin Farzaneh‐Far, E. Douglas Lewandowski, Samuel C. Dudley
Format: Article
Language:English
Published: Wiley 2016-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
diastolic dysfunction
insulin resistance
mitochondrial oxidative stress
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.003046

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.115.003046

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