Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors.

Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors.

To achieve effective active targeting in a drug delivery system, we previously developed dual-targeting (DT) liposomes decorated with both vascular endothelial growth factor receptor-1 (VEGFR-1)-targeted APRPG and CD13-targeted GNGRG peptide ligands for tumor neovessels, and observed the enhanced su...

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Bibliographic Details
Main Authors: Tomoki Sugiyama, Tomohiro Asai, Yuki Murase Nedachi, Yasufumi Katanasaka, Kosuke Shimizu, Noriyuki Maeda, Naoto Oku
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3695877?pdf=render

Internet

http://europepmc.org/articles/PMC3695877?pdf=render

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