CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate

CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate

Abstract The nuclear receptor subfamily 5 group A member 1 (NR5A1), encoding steroidogenic factor 1 (SF-1), has been identified as a critical factor in gonadal development in animal studies. A previous study of ours suggested that upregulation of NR5A1 during early gonadal differentiation in male (4...

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Bibliographic Details
Main Authors: Laura Danti, Karolina Lundin, Kirsi Sepponen, Dawit A. Yohannes, Juha Kere, Timo Tuuri, Juha S. Tapanainen
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Ovarian Research
Subjects:
CRISPR
NR5A1
SF-1
Orphan nuclear receptor
Ovary
Testis
Online Access:https://doi.org/10.1186/s13048-023-01264-5

Internet

https://doi.org/10.1186/s13048-023-01264-5

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