BLNK mutation associated with T-cell LGL leukemia and autoimmune diseases: Case report in hematology

BLNK mutation associated with T-cell LGL leukemia and autoimmune diseases: Case report in hematology

We present the case of a female patient with a heterozygous somatic BLNK mutation, a T-cell LGL (large granular lymphocyte) leukemia, and multiple autoimmune diseases. Although this mutation seems uncommon especially in this kind of clinical observation, it could represent a new mechanism for autoim...

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Bibliographic Details
Main Authors: Guillemette Fouquet, Julien Rossignol, Laure Ricard, Flavia Guillem, Lucile Couronné, Vahid Asnafi, Manon Vavasseur, Mélanie Parisot, Nicolas Garcelon, Frédéric Rieux-Laucat, Arsène Mekinian, Olivier Hermine
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Medicine
Subjects:
B-cell linker
large granular lymphocyte leukemia
autoimmune diseases
regulatory B-cells
regulatory T-cells (T reg)
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.997161/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.997161/full

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