Expression of Bruton´s tyrosine kinase in different type of brain lesions of multiple sclerosis patients and during experimental demyelination

Expression of Bruton´s tyrosine kinase in different type of brain lesions of multiple sclerosis patients and during experimental demyelination

BackgroundInhibition of Bruton’s tyrosine kinase (BTK) is an emerging multiple sclerosis (MS) therapy. BTK inhibitors (BTKi) cross the blood-brain barrier and modulate B cells and microglia, major cellular players in active and chronic active lesions.ObjectiveTo assess potential lesional and cellula...

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Bibliographic Details
Main Authors: Maria L. Elkjaer, Mie R. Waede, Christina Kingo, Karina Damsbo, Zsolt Illes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
smoldering MS
Bruton´s tyrosine kinase
white matter
brain lesions
microglia
B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1264128/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1264128/full

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